LINKAGE OF EARLY-ONSET FAMILIAL BREAST CANCER TO CHROMOSOME 17Q21 PDF

PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.

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Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease. Chromosme, for late-onset cases, chromoosome relative probability of sporadic rather than inherited disease chromsome higher than previously suggested.

If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.

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There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset. National Center for Biotechnology InformationU. Am J Hum Genet.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Author information Copyright and License information Chromosomee. This article has been corrected. See Am J Hum Genet. This article has been cited by other articles in PMC.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.

Segregation and linkage analysis of nine Utah breast cancer pedigrees. Genetic analysis of breast cancer in the cancer and steroid hormone study. Closing in on a breast cancer gene on chromosome 17q.

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Linkage of early-onset familial breast cancer to chromosome 17q21.

Linkage of early-onset familial breast cancer to chromosome 17q Genetic epidemiology of breast cancer in Britain. Strategies for multilocus linkage analysis in humans. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.

Estimating the power of linkage analysis in hereditary breast cancer. Familial breast-ovarian cancer locus on chromosome 17qq Inheritance of human breast cancer: A new statistical test for linkage heterogeneity. Inheritance of proliferative breast disease in breast cancer kindreds.

Linkage of early-onset familial breast cancer to chromosome 17q

Genetic epidemiology of breast cancer: Associated Data Supplementary Materials. Open in a separate window. Support Center Support Center. Please review our privacy policy.