Range Description: The species is present in the Mediterranean region (southern Europe, western Asia and northern Africa), especially on the western side (e.g. Category: cosmetic ingredient for skin conditioning. Recommendation for globularia alypum leaf extract usage levels up to: not for fragrance use. Globularia alypum methanolic extract improves burn wound healing process and inflammation in rats and possesses antibacterial and.

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It is suggested that the G. New iridoid glucosides and a lignan diglucoside from Globularia alypum L. Globularia is a genus of about 22 species of flowering plants in the family Plantaginaceaenative to central and southern Europe, Macaronesia, northwest Africa and southwest Asia. Two more results argue in favor of G. It has not also been observed any fibrosis or siderosis.

GA is widely used in folk medicine against skin diseases and abscesses, however there is no scientific evidence justifying its use. Muscular strength, body composition and health responses to the use of testosterone enanthate: Although the mechanism of action of androgens on lipids metabolism is not totally elucidated, it is reported that androgens may cause dyslipidemia,[ 26 ] can activate adipocytes lipase[ 27 ] and increase the release of free fatty acids.

This study aimed to evaluate the wound healing and anti-inflammatory effect, the antibacterial and antioxidant activities, as well as the chemical compositions of GA methanolic extract GAME.

globularix The animals, observed for 14 days following the unique administration of the tested drug, received a standardized food Animal Alimentation Society—SNA—Borj Cidria, Tunisia and fresh water ad libitum. Hence, this work has been performed to evaluate the toxicity of the drug in animals.

Hypoglycaemic activity of Globularia alypum leaves in rats. J Acquir Immune Defic Syndr.

globularia alypum leaf extract

Ben Merabet K, Abed A. Toxicity study by reiterated administrations in rats Administration of the product This study has been undertaken in male and female Wistar rats, divided in six groups of 10 rats each according to the following protocol: It has also to be pointed alyupm that the observed vascular congestion was nearly constant in the all the groups of animals treated with G.


Since, on the one hand, androgens are known to possess anabolic effects by increasing protein synthesis from amino acids[ 22 — 24 ] and to cause glucose metabolism troubles with insulin resistance[ 2526 ] on the other hand, it is therefore possible to attribute that the recorded active spermatogenesis could result from an androgenic effect induced by the drug.

This study is divided in globularria parts: High performance liquid chromatography analysis of globularin in Globularia alypum L. During the treatment period, a control group of 10 male rats weighing The homogenate was centrifuged for 30 min at g and the supernatant filtered and lyophilized. Through an intra-peritoneal route, G.

Hematocrit and hemoglobin were respectively determined by means of the gravity and cyanmethemoglobin method. Moreover and in certain cases, it has been used the following histo-chemical colorations: The acute toxicity study showed that when G.

Aromatic acids and the flavonoid compounds of the leaves of the globe daisy Globularia alypum Plant Med Phytother.

A potential antileukemic substance present in Globularia alypum L. Retrieved from ” https: A total of 17 compounds were identified.

The eluent was monitored at nm with complete UV absorbance spectra of each eluting peak available between and Histological examination at this level revealed a thinning down of the esophageal wall and an atrophy of the muscular coat. Plants have been considered as potential agents for prevention and treatment of disorders in recent years.

Balansard J, Delphant J. Quasi total absence of spermatozoa and germinal cells in seminiferous tubules, b Epididymis devoid of spermatozoa, c Non active spermatogenesis: On the opposite, the observed altpum spaces eosinophil granulocytes invasion corresponding probably to a beginning of a ARDS selectively affected male than female rats.


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This result may suggest that a very globularja toxicity of the drug when given orally. No mortality was observed in all experimental animal groups. In other projects Wikimedia Commons Wikispecies. Histopathological examination of the organs removed at the end of the treatment revealed, in comparison with the control groups, the existence of important histological modifications induced by the chronic administration of the drug.

This observation confirms the purgative and laxative properties related to the drug and reported by Balansard and Delphaut. Laboratory 35, Rue de Palestine, Tunis, Tunisia for biochemical and hematological analysis. Following this observation, it has been decided to conduct another study by reducing the administered dose and globularja treatment period.

Thus, this study confirms its traditional use, however further more precise studies are needed for future clinical application. The second toxic effect of the drug was observed gloublaria the lung where histopathological examination demonstrated a pronounced thinning of pulmonary arteriolar wall responsible of PHT affecting selectively female than male rats.

Toxicity study Acute toxicity No mortality was observed in experimental animals when the drug was orally administered.

Globularia – Wikipedia

Globularia species are used as food plants glkbularia the larvae of some Lepidoptera species including Coleophora virgatella. The first one is concerned by the recorded hyperprotidemia and hyperglycemia. Articles with ‘species’ microformats All stub articles. Fehri B, Aiache JM. GAME-treated rats showed an improvement in healing process and carrageenan-induced hind paws edema as assessed by histological and biochemical investigations, compared to the control.