Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.
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In patients treated with methadone for opioid use disorder, cessation of benzodiazepines or other CNS depressants is preferred in most cases. Consider dose reduction of diazepam if clinically indicated. The intensity of sedation and orthostatic hypotension is greater during concurrent use of lorazepam and oral aripiprazole and during use of a parenteral benzodiazepine and intramuscular IM aripiprazole compared to aripiprazole alone; therefore, patients receiving a benzodiazepine with oral or parenteral aripiprazole should be monitored for sedation and blood pressure and the dose should be adjusted accordingly.
Diastat (diazepam) dose, indications, adverse effects, interactions from
In geriatric and debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation, and that close monitoring be employed. Tricyclic antidepressants may also lower the seizure threshold leading to pharmacodynamic interactions with anticonvulsant benzodiazepines i.
When a medication is used to manage behavior, stabilize mood, or treat a psychiatric disorder, the facility should attempt periodic tapering of the medication or provide documentation of medical necessity in accordance with OBRA guidelines. Monitor patients for decreased pressor effect if these agents are administered concomitantly. The combined use of alcohol and CNS depressants can lead to additive CNS depression, which could be dangerous in tasks requiring mental alertness and fatal in overdose.
For tetanus, larger doses may be required.
Moderate Because promethazine causes pronounced sedation, an enhanced CNS depressant effect or additive drowsiness may occur when it is combined with other CNS depressants including benzodiazepines. Moderate Advise patients that concurrent use of deutetrabenazine and drugs that can cause CNS depression, such as diazepam, may have additive effects and worsen drowsiness or sedation.
Moderate Monitor for an increase in diazepam-related adverse reactions including sedation and respiratory depression if coadministration with rucaparib is necessary. Moderate Methyldopa is associated with sedative effects.
Benzodiazepines should be used cautiously in patients with bipolar disorder because mania and hypomania have been reported in conjunction with the use of benzodiazepines in depressive disorders.
Use these drugs cautiously with MAOIs; warn patients to not drive or perform other hazardous activities until they know how a particular drug combination affects them.
Some experts suggest that occasional maternal treatment with usual doses of lorazepam or oxazepam would pose little risk to a breast-feeding infant. Turn person on side facing you and bend upper leg forward inforrmation expose rectum.
Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Ciprofloxacin has been shown to decrease the clearance and increase the half-life of diazepam. In theory, dosage reductions may be required for drugs that siastat largely eliminated via CYP2C19 metabolism such as diazepam during coadministration with armodafinil.
Benzodiazepines should be withdrawn slowly, using a gradual dosage-tapering schedule. Moderate Use caution if the use of benzodiazepines are necessary with dronabinol, and informtaion for additive dizziness, confusion, somnolence, and other CNS effects.
Animal studies of the anticonvulsant actions suggest that benzodiazepines augment presynaptic inhibition of neurons, thereby limiting the spread of electrical activity, although they do not actually inhibit the abnormally discharging doastat. Moderate Use clobazam with other benzodiazepines with caution due to the potential for increased risk of drowsiness and sedation. Benzodiazepines that are not metabolized by CYP3A4 such as oxazepam or lorazepam may be alternatives if a benzodiazepine is required in combination prwscribing St.
In addition, sleep-related behaviors, such as sleep-driving, are more likely to occur during concurrent use of zolpidem and other CNS depressants than with zolpidem alone. Coadminister these drugs with caution, closely monitoring the patient for adverse effects related to diazepam; a decrease in diazepam dose may be needed.
Diastat® AcuDial™: Breakthrough Seizure Control
If a large vein is not available, inject into the tubing of a prescrribing IV solution as close as possible to the vein insertion.
Moderate Drugs that can cause CNS depression, if used concomitantly with paliperidone, can increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, and dizziness. According to the Beers Criteria, benzodiazepines are considered potentially inappropriate medications PIMs for use in geriatric patients and avoidance is generally recommended, although some agents from this class may be appropriate for seizure disorders, rapid eye movement sleep disorders, benzodiazepine withdrawal, severe generalized anxiety disorder, peri-procedural anesthesia, and end of life care.
Alternatively, conversion to buspirone therapy may require diaatat overlap to allow for the downward titration of the benzodiazepine while buspirone takes effect. If a benzodiazepine is necessary, a dosage adjustment of the multi-day regimen may be necessary depending on the clinical situation e.
Dosage should be modified depending on clinical response and degree of renal impairment, but no quantitative recommendations are fiastat active and inactive diazepam metabolites are excreted by the kidney. Educate patients about the risks and symptoms of respiratory depression and sedation.
Diazepam emulsified injection should be prepared for single prescriblng use only. Moderate Co-administration of dexmedetomidine with benzodiazepines is likely to lead to an enhancement of CNS depression. Moderate Coadministration can potentiate the CNS effects e.
Moderate Concomitant use of nabilone with other CNS depressants can potentiate the effects of nabilone on respiratory depression. Moderate Drugs that can cause CNS depression, if used concomitantly with asenapine, may increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, and dizziness. Caution should be used when paliperidone is given in combination with other centrally-acting medications including anxiolytics, sedatives, and hypnotics, buprenorphine, butorphanol, dronabinol, THC, ethanol, nabilone, nalbuphine, opiate agonists, and pentazocine.